you have had a severe allergic reaction after a previous dose of the vaccine. You should not get the COVID-19 vaccine if: However, some people have experienced non-severe allergic reactions (i.e., hives, swelling, and wheezing) within four hours after getting vaccinated. If a severe allergic reaction does occur, it typically happens within a few minutes to one hour after receiving the vaccine. Severe allergic reactions or anaphylaxis to vaccines are extremely uncommon. More information will become available once we know more. Clinical trials for these vaccines are ongoing. No harmful side effects have been reported in clinical trials, however, the possibility of extremely rare harmful side effects could still exist. Side effects were usually short-lived and able to be managed with fever-reducing medications, such as Tylenol. For people who received the Pfizer/BioNTech, Novavax, or Moderna vaccine, side effects were more common after the second dose than the first dose. Some people who received the vaccine reported worse fevers and aches than others. swollen lymph nodes in the same arm as the injection site (seen in Moderna clinical trials). nausea (seen in Moderna clinical trials) and. diarrhea (seen in Pfizer/BioNTech clinical trials). mild pain, swelling, or redness at the injection site where you get the vaccine. 2018.Participants in both the Pfizer/BioNTech and Moderna vaccine clinical trials have reported the following side effects: Interferon regulatory factor 1 inactivation in human cancer. p16 controls p53 protein expression through miR-dependent destabilization of MDM2. Immune thrombocytopenia associated with Pfizer-BioNTech’s BNT162b2 mRNA COVID-19 vaccine. doi: 10.1093/molbev/mss273.Īkiyama H., Kakiuchi S., Rikitake J., Matsuba H., Sekinada D., Kozuki Y., Iwata N. Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme. MicroRNAs and neurodegeneration: role and impact. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.Ĭancer Exosomes G-quadruplexes SARS-CoV-2 mRNA vaccines Type I interferon Response microRNAs.Ĭopyright © 2022 The Authors. 
We show evidence from the VAERS database supporting our hypothesis.
These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance.
Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19.
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